Open AccessTransmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle
Author(s) -
Alexey V. Glukhov,
Vadim V. Fedorov,
Qing Lou,
Vinod K. Ravikumar,
Paul W. Kalish,
Richard B. Schuessler,
Nader Moazami,
Igor R. Efimov
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.204891
Subject(s) - ventricle , repolarization , cardiology , medicine , dispersion (optics) , ventricular repolarization , electrophysiology , physics , optics
Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important contributor to the HF phenotype. However, there is limited electrophysiological data from the human heart.
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