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Hypertrophic cardiomyopathy is a genetically heterogeneous myocardial disease with &gt;1000 causal variants identified. Nonunique variants account for disease in many families. We sought to characterize nonunique variants in Australian families and determine whether they arise from common ancestral mutations or recurrent mutation events.

Burden of Recurrent and Ancestral Mutations in Families With Hypertrophic Cardiomyopathy