Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI | Zendy

Benjamin F.J. Verhaaren | Zendy; Stéphanie Debette | Zendy; Joshua C. Bis | Zendy; Jennifer A. Smith | Zendy; M. Kamran Ikram | Zendy; Hieab H.H. Adams | Zendy; Ashley Beecham | Zendy; Kumar B. Rajan | Zendy; Lorna M. Lopez | Zendy; Sandra Barral | Zendy; Mark A. van Buchem | Zendy; Jeroen van der Grond | Zendy; Albert V. Smith | Zendy; Katrin Hegenscheid | Zendy; Neelum T. Aggarwal | Zendy; Mariza de Andrade | Zendy; Elizabeth J. Atkinson | Zendy; Marian Beekman | Zendy; Alexa S. Beiser | Zendy; Susan H. Blanton | Zendy; Eric Boerwinkle | Zendy; Adam M. Brickman | Zendy; R. Nick Bryan | Zendy; Ganesh Chauhan | Zendy; Christopher Chen | Zendy; Vincent Chouraki | Zendy; Anton J. M. de Craen | Zendy; Fabrice Crivello | Zendy; Ian J. Deary | Zendy; Joris Deelen | Zendy; Philip L. De Jager | Zendy; Carole Dufouil | Zendy; Mitchell S.V. Elkind | Zendy; Denis A. Evans | Zendy; Paul Freudenberger | Zendy; Rebecca F. Gottesman | Zendy; Vilmundur Guðnason | Zendy; Mohamad Habes | Zendy; Susan R. Heckbert | Zendy; Gerardo Heiss | Zendy; Saima Hilal | Zendy; Edith Hofer | Zendy; Albert Hofman | Zendy; Carla A. IbrahimVerbaas | Zendy; David S. Knopman | Zendy; Cora E. Lewis | Zendy; Jiemin Liao | Zendy; David C. Liewald | Zendy; Michelle Luciano | Zendy; Aad van der Lugt | Zendy; Oliver Martinez | Zendy; Richard Mayeux | Zendy; Bernard Mazoyer | Zendy; Mike A. Nalls | Zendy; Matthias Nauck | Zendy; Wiro J. Niessen | Zendy; Ben A. Oostra | Zendy; Bruce M. Psaty | Zendy; Kenneth Rice | Zendy; Jerome I. Rotter | Zendy; Bettina von Sarnowski | Zendy; Helena Schmidt | Zendy; Pamela J. Schreiner | Zendy; Maaike Schuur | Zendy; Stephen Sidney | Zendy; Sigurður Sigurðsson | Zendy; P. Eline Slagboom | Zendy; David J.M. Stott | Zendy; John C. van Swieten | Zendy; Alexander Teumer | Zendy; Anna Maria Töglhofer | Zendy; Matthew Traylor | Zendy; Stella Trompet | Zendy; Stephen T. Turner | Zendy; Christophe Tzourio | Zendy; HaeWon Uh | Zendy; André G. Uitterlinden | Zendy; Meike W. Vernooij | Zendy; Jing Jing Wang | Zendy; Tien Yin Wong | Zendy; Joanna M. Wardlaw | Zendy; B. Gwen Windham | Zendy; Katharina Wittfeld | Zendy; Christiane Wolf | Zendy; Clinton B. Wright | Zendy; Qiong Yang | Zendy; Wei Zhao | Zendy; Alex Zijdenbos | Zendy; J. Wouter Jukema | Zendy; Ralph L. Sacco | Zendy; Sharon L. R. Kardia | Zendy; Philippe Amouyel | Zendy; Thomas H. Mosley | Zendy; W. T. Longstreth | Zendy; Charles DeCarli | Zendy; Cornelia M. van Duijn | Zendy; Reinhold Schmidt | Zendy; Lenore J. Launer | Zendy; Hans J. Grabe | Zendy; Sudha Seshadri | Zendy; M. Arfan Ikram | Zendy; Myriam Fornage | Zendy

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Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Author(s) -

Benjamin F.J. Verhaaren,

Stéphanie Debette,

Joshua C. Bis,

Jennifer A. Smith,

M. Kamran Ikram,

Hieab H.H. Adams,

Ashley Beecham,

Kumar B. Rajan,

Lorna M. Lopez,

Sandra Barral,

Mark A. van Buchem,

Jeroen van der Grond,

Albert V. Smith,

Katrin Hegenscheid,

Neelum T. Aggarwal,

Mariza de Andrade,

Elizabeth J. Atkinson,

Marian Beekman,

Alexa S. Beiser,

Susan H. Blanton,

Eric Boerwinkle,

Adam M. Brickman,

R. Nick Bryan,

Ganesh Chauhan,

Christopher Chen,

Vincent Chouraki,

Anton J. M. de Craen,

Fabrice Crivello,

Ian J. Deary,

Joris Deelen,

Philip L. De Jager,

Carole Dufouil,

Mitchell S.V. Elkind,

Denis A. Evans,

Paul Freudenberger,

Rebecca F. Gottesman,

Vilmundur Guðnason,

Mohamad Habes,

Susan R. Heckbert,

Gerardo Heiss,

Saima Hilal,

Edith Hofer,

Albert Hofman,

Carla A. IbrahimVerbaas,

David S. Knopman,

Cora E. Lewis,

Jiemin Liao,

David C. Liewald,

Michelle Luciano,

Aad van der Lugt,

Oliver Martinez,

Richard Mayeux,

Bernard Mazoyer,

Mike A. Nalls,

Matthias Nauck,

Wiro J. Niessen,

Ben A. Oostra,

Bruce M. Psaty,

Kenneth Rice,

Jerome I. Rotter,

Bettina von Sarnowski,

Helena Schmidt,

Pamela J. Schreiner,

Maaike Schuur,

Stephen Sidney,

Sigurður Sigurðsson,

P. Eline Slagboom,

David J.M. Stott,

John C. van Swieten,

Alexander Teumer,

Anna Maria Töglhofer,

Matthew Traylor,

Stella Trompet,

Stephen T. Turner,

Christophe Tzourio,

HaeWon Uh,

André G. Uitterlinden,

Meike W. Vernooij,

Jing Jing Wang,

Tien Yin Wong,

Joanna M. Wardlaw,

B. Gwen Windham,

Katharina Wittfeld,

Christiane Wolf,

Clinton B. Wright,

Qiong Yang,

Wei Zhao,

Alex Zijdenbos,

J. Wouter Jukema,

Ralph L. Sacco,

Sharon L. R. Kardia,

Philippe Amouyel,

Thomas H. Mosley,

W. T. Longstreth,

Charles DeCarli,

Cornelia M. van Duijn,

Reinhold Schmidt,

Lenore J. Launer,

Hans J. Grabe,

Sudha Seshadri,

M. Arfan Ikram,

Myriam Fornage

Publication year - 2015

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.114.000858

Subject(s) - hyperintensity , genome wide association study , white matter , association (psychology) , genetic association , medicine , magnetic resonance imaging , biology , genetics , single nucleotide polymorphism , psychology , genotype , gene , radiology , psychotherapist

The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies.

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