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The stability and detectability of circulating microRNAs in human plasma provides exciting opportunities for the use of microRNAs as biomarkers for human disease. In an exploratory study, we have investigated the behavior of selected microRNAs, including the cardiac-enriched microRNAs −208b and −499 in a panel of cardiovascular diseases and found a striking elevation of the latter 2 microRNAs in plasmas of patients with acute myocardial infarction.1Multiple groups have published concordant findings about the diagnostic accuracy of both microRNAs in the setting of acute myocardial infarction.2,3 However, differences in isolation efficiency …

Response to Letter Regarding Article, “Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease”