Open AccessLoss of Cardiomyocyte Integrin-Linked Kinase Produces an Arrhythmogenic Cardiomyopathy in Mice
Author(s) -
Khaï Le Quang,
Ange Maguy,
Xiaoyan Qi,
Patrice Naud,
Feng Xiong,
Artavazd Tadevosyan,
Yanfen Shi,
Denis Chartier,
JeanClaude Tardif,
Dobromir Dobrev,
Stanley Nattel
Publication year - 2015
Publication title -
circulation arrhythmia and electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.684
H-Index - 102
eISSN - 1941-3149
pISSN - 1941-3084
DOI - 10.1161/circep.115.001668
Subject(s) - integrin linked kinase , knockout mouse , medicine , ventricle , endocrinology , electrophysiology , cardiomyopathy , biology , kinase , protein kinase a , microbiology and biotechnology , heart failure , receptor , cyclin dependent kinase 2
Integrin-linked kinase (ILK), a serine/threonine protein kinase, has roles in cell signaling and molecular scaffolding. ILK mutation/deletion causes cardiomyopathic phenotypes, but the functional and electrophysiological features have not been characterized. This study investigated the structural, functional, ion channel, and electrophysiological changes associated with cardiomyocyte-directed ILK deletion in mice.
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