Open AccessSodium Channelopathy Underlying Familial Sick Sinus Syndrome With Early Onset and Predominantly Male Characteristics
Author(s) -
Keisuke Abé,
Taku Machida,
Naokata Sumitomo,
Hirokazu Yamamoto,
Kimie Ohkubo,
Ichiro Watanabe,
Takeru Makiyama,
Satoki Fukae,
Masaki Kohno,
Daniel Toshio Harrell,
Taisuke Ishikawa,
Yukiomi Tsuji,
Akihiko Nogami,
Taichi Watabe,
Yasushi Oginosawa,
Haruhiko Abe,
Koji Maemura,
Hideki Motomura,
Naomasa Makita
Publication year - 2014
Publication title -
circulation arrhythmia and electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.684
H-Index - 102
eISSN - 1941-3149
pISSN - 1941-3084
DOI - 10.1161/circep.113.001340
Subject(s) - sss* , channelopathy , brugada syndrome , proband , sick sinus syndrome , medicine , genetics , mutation , biology , gene
Sick sinus syndrome (SSS) is a common arrhythmia often associated with aging or organic heart diseases but may also occur in a familial form with a variable mode of inheritance. Despite the identification of causative genes, including cardiac Na channel (SCN5A), the pathogenesis and molecular epidemiology of familial SSS remain undetermined primarily because of its rarity.
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