Open AccessArrhythmia Phenotype During Fetal Life Suggests Long-QT Syndrome Genotype
Author(s) -
Bettina F. Cuneo,
Susan P. Etheridge,
Hitoshi Horigome,
Denver Sallee,
Anita J. MoonGrady,
HsinYi Weng,
Michael J. Ackerman,
D. Woodrow Benson
Publication year - 2013
Publication title -
circulation arrhythmia and electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.684
H-Index - 102
eISSN - 1941-3149
pISSN - 1941-3084
DOI - 10.1161/circep.113.000618
Subject(s) - sinus bradycardia , medicine , bradycardia , long qt syndrome , atrioventricular block , torsades de pointes , qt interval , cardiology , heart block , fetus , heart rate , sinus rhythm , gestational age , fetal echocardiography , anesthesia , electrocardiography , prenatal diagnosis , pregnancy , atrial fibrillation , biology , blood pressure , genetics
Fetal arrhythmias characteristic of long QT syndrome (LQTS) include torsades de pointes (TdP) and/or 2° atrioventricular block, but sinus bradycardia, defined as fetal heart rate<3% for gestational age, is most common. We hypothesized that prenatal rhythm phenotype might predict LQTS genotype and facilitate improved risk stratification and management.
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