Open AccessDocosahexaenoic Acid, but Not Eicosapentaenoic Acid, Supplementation Reduces Vulnerability to Atrial Fibrillation
Author(s) -
Andrew Ramadeen,
Kim A. Connelly,
Howard LeongPoi,
Xudong Hu,
Hiroko Fujii,
Gabriel Laurent,
Anthony F. Domenichiello,
Richard P. Bazinet,
Paul Dorian
Publication year - 2012
Publication title -
circulation arrhythmia and electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.684
H-Index - 102
eISSN - 1941-3149
pISSN - 1941-3084
DOI - 10.1161/circep.112.971515
Subject(s) - docosahexaenoic acid , eicosapentaenoic acid , polyunsaturated fatty acid , atrial fibrillation , medicine , cardiology , fatty acid , endocrinology , chemistry , biochemistry
The potential health benefits of ω-3 polyunsaturated fatty acids (PUFAs) usually are studied using a combination of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). This combination reduces vulnerability to experimentally induced atrial fibrillation (AF). It is unknown whether EPA and DHA have differential effects when taken alone. Using a model of pacing-induced atrial hemodynamic overload, we investigated the individual effects of EPA and DHA on vulnerability to AF and atrial remodeling.
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