Open AccessAdrenergic Receptor Polymorphisms and Prevention of Ventricular Arrhythmias With Bucindolol in Patients With Chronic Heart Failure
Author(s) -
Ryan G. Aleong,
William H. Sauer,
A. Robertson,
Stephen B. Liggett,
Michael R. Bristow
Publication year - 2012
Publication title -
circulation arrhythmia and electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.684
H-Index - 102
eISSN - 1941-3149
pISSN - 1941-3084
DOI - 10.1161/circep.111.969618
Subject(s) - medicine , ejection fraction , ventricular tachycardia , heart failure , cardiology , ventricular fibrillation , genotype , atrial fibrillation , sympatholytic , adrenergic , adrenergic receptor , tolerability , adverse effect , receptor , chemistry , blood pressure , biochemistry , gene
β-blockers prevent cardiac arrhythmias in patients with chronic heart failure and reduced left ventricular ejection fraction, including ventricular tachycardia/ventricular fibrillation (VT/VF). We hypothesized that prevention of ventricular arrhythmias by the β-blocker/sympatholytic agent bucindolol is influenced by genetic variation in adrenergic receptors.
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