Open AccessReduced Ventricular Proarrhythmic Potential of the Novel Combined Ion-Channel Blocker AZD1305 Versus Dofetilide in Dogs With Remodeled Hearts
Author(s) -
Daniel M. Johnson,
Monique M.J. de Jong,
Harry J.G.M. Crijns,
Leif Carlsson,
Paul G.A. Volders
Publication year - 2011
Publication title -
circulation arrhythmia and electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.684
H-Index - 102
eISSN - 1941-3149
pISSN - 1941-3084
DOI - 10.1161/circep.111.963025
Subject(s) - dofetilide , torsades de pointes , cardiology , medicine , atrioventricular block , sinus rhythm , qt interval , atrial fibrillation , anesthesia
AZD1305 is an investigational antiarrhythmic agent for management of atrial fibrillation. It blocks various cardiac ion currents at different potencies and has atrial-predominant electrophysiological effects. We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic complete atrioventricular block and myocardial hypertrophic remodeling.
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