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Electric alternans is a pattern of variation in the shape of ECG waveform that occurs every other beat. In humans, alternation in ventricular repolarization, known as repolarization alternans (RA), has been associated with increased vulnerability to ventricular tachycardia/fibrillation and sudden cardiac death.

A Novel Lead Configuration for Optimal Spatio-Temporal Detection of Intracardiac Repolarization Alternans