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0030 Major lipoprotein classes consist of particles of various  sizes, densities and composition. Associations between lipoprotein  subclasses and coronary calcification were evaluated in 287 healthy  women, 8 years post-menopause (age 56.9 to 65.4, mean=61.7 y). Coronary  calcification score (CCS) was measured by electron beam CT and  lipoprotein subclasses were determined by NMR spectroscopy. The mean  CCS was 53 (range 0-1175) but 54% of the women had zero scores. CCS  was analyzed as categories (CCS: 0, 1-99, ≥100). Current smoking was  strongly associated with greater CCS but age and SBP were not  significantly associated. Higher CCS was associated with higher  triglycerides, total cholesterol and LDL-C, by NMR or usual methods,  and total HDL-C by usual methods at the same visit (p   100). The number of LDL  particles was also strongly related to CCS (p  27 mg/dL were more likely to be in a higher CCS category  than those without these risk factors (OR = 2.09, 95% CI: 1.18,  3.70; OR= 2.21, 95% CI: 1.19,4.10, respectively.) After adjustment,  higher CCS was still related to higher levels of small LDL (L1), but  not to mean (LDL) particle size. These relationships were confirmed  using linear regression with log-transformed variables. In  postmenopausal women the size and number of LDL particles may be better  predictors of atherosclerosis than total LDL-C. The level of large VLDL  triglyceride contributes to decreased LDL size and increased number of  LDL particles at a given level of LDL-C, via CETP and hepatic  lipase.

LDL subclass distribution is associated with coronary calcification in postmenopausal women