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P91 The decision to take hormone replacement therapy (HRT) is a  choice many women encounter when entering menopause. In light of  controversy of the benefits and risks of HRT use, an important question  to ask is on what basis are women taking HRT, and are they taking  hormone therapy because they are at higher risk. The purpose of this  study was to examine HRT use in women who are participating in a  behavioral lifestyle intervention through the menopause. The Women’s  Healthy Lifestyle Project (WHLP) was a 5-year randomized clinical trial  designed to examine whether a behavioral lifestyle intervention could  decrease the expected rise in cardiovascular risk through the  menopause. A sample of 535 healthy premenopausal women, aged 44-50  years (M=47 + 1.9) participated in the study. The intervention was  highly successful in buffering risk elevation through the 54-month  visit. The control group gained 5.2 lb over the 54 month study and the  intervention group remained 0.18 lb below baseline (p=.00). The  intervention group’s LDLc increased by 3.5 mg/dl, and the control  group’s LDLc increased by 8.9 mg/dl (p=.01). At the 54-month visit,  there was no difference between the intervention and control groups in  menopausal status, with 34.7% of the women postmenopausal. There was  no difference between intervention and control groups with regard to  HRT use, with 31.2% of the total sample reporting use of HRT. Further,  there was no difference in menopausal symptoms between treatment  groups. The women started HRT an average of 6 months after they missed  a period. Analysis was done to examine predictors of HRT use in this  group of women. Baseline cardiovascular risk factors did not predict  HRT use at the 54-month visit. Moreover, the number of menopausal  symptoms did not predict HRT use at 54 months. There was little  difference between the women who were taking HRT and the women who were  not taking HRT. There was a high use of HRT in this group of healthy,  well-educated women. But an intensive lifestyle intervention did not  change the use of HRT.

Hormone Therapy and Menopausal Symptoms Among Women Participating in a Behavioral Lifestyle Intervention: The Women’s Healthy Lifestyle Project