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P74 Background. While exercise during leisure is a consistent  protective factor for CVD, there is inconsistency across studies  concerning the impact of physical activity during work. The current  study investigated the relationship between progression of sub-clinical  atherosclerosis and physical activity during work and during leisure  time. Methods. Participants were from a cohort of 573 randomly sampled  utility workers asymptomatic for CVD who were aged 40-60 years at  entry. Physical activity during leisure was determined from the number  of times per week the subject reported working up a sweat; physical  activity during work was ascertained from an NHLBI Physical Activity  Index. Sub-clinical atherosclerosis was measured as intima-media  thickness (IMT) of the common carotid arteries by high resolution  B-mode ultrasound. 36 month change in IMT was measured in microns per  year. Results. The mean (±SD) IMT in the sample with complete  follow-up (n=447) was 678±106 μm. Those scoring in the highest  quintile of workplace activity had significantly more IMT  progression compared with those in the lowest quintile (mean±SE =  13.0±1.8 vs 6.9±1.8 μm/yr, respectively; p for trend=0.02 in a  model adjusted for age, sex, age-sex interaction, smoking status,  alcohol use, use of blood pressure and/or cholesterol lowering  medications, BMI, HDL-c, total serum cholesterol, heart rate, systolic  blood pressure, and intake of supplemental vitamin C and E). For  leisure activity, significantly less IMT progression was  found with more activity, but only among those in the highest quintile  of activity relative to those in the other 4 quintiles (6.5±1.8 vs  10.9±0.9 μm/yr; p=0.03 in a model adjusted for the same covariates  listed above). No significant interaction with sex was detected.  Workplace activity was strongly correlated with workplace psychological  stress (ρ=0.56), which was previously shown to be a risk factor for  IMT in this cohort. Conclusions. These findings suggest that protective  effects of physical activity may be blocked or counteracted when  activity is performed in a psychologically stressful  context.

Workplace and Leisure Time Physical Activity: Opposing Relations with Progression of Early Atherosclerosis. The Los Angeles Atherosclerosis Study.