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P61 Inflammation is thought to play a crucial role in the  pathogenesis of coronary atherosclerosis. Asthma is a chronic  inflammatory disease and a major cause of pulmonary morbidity and  mortality. However, very few prospective studies exist evaluating the  question of whether asthma is related to increased risk of  cardiovascular diseases, and none were restricted to never smokers. We  examined the prospective association between self-reported asthma  diagnosis and risk of hospitalization and/or death due to coronary  heart disease (CHD, ICD-9 codes 410-414) in a large population-based  sample. Data on self-reported health conditions, including asthma, and  cardiovascular risk factors were collected at a health maintenance  organization (HMO) in the San Francisco Bay Area between 1979 and 1985.  The sample included 14,047 never smoking women and 7,989 never smoking  men aged 35-89 years (mean ± SD, 50.4 ± 11.9 years), 56%  Caucasian, who were free of known CHD at baseline. Of those, 652 women  (4.6%) and 410 men (5.1%) self-reported physician-diagnosed asthma.  Follow-up for hospitalization and/or death was available through the  end of 1998 (median=13.4 years). Using Cox proportional hazards  regression, we censored persons leaving the health plan at their last  known date of HMO membership. Compared to subjects with no-known  history of asthma, and after adjustment for age, sex, race, education  level, alcohol consumption, body mass index, serum cholesterol,  systolic blood pressure and diabetes, self-reported asthma was  significantly associated with higher risk of hospitalization and /or  death due to CHD (RR=1.33; 95% CI=1.05-1.67; p=0.02). Also in  multivariate analysis, asthma under treatment at the time of the  baseline examination was more strongly associated with CHD risk  (RR=1.82; 95% CI=1.23-2.69; p=0.003). No interactions were found  between self-reported asthma or asthma under treatment and patient sex.  We conclude that, in a large representative population-based sample of  non-smokers, self-reported asthma was associated with increased risk of  coronary heart disease.

circulation

Self-reported Asthma is Associated with Increased Risk of Hospitalization and/or Death Due to Coronary Heart Disease among Never Smoking Men and Women.