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P32 We sought to investigate the association between periodontal  disease (PD) and total and cardiovascular (CV) mortality in a large  cohort of men. Methods: Of 104,388 men in the Physician s Health Study  enrollment cohort, 88,882 who had no history of cancer, myocardial  infarction, stroke or liver disease and provided information on PD were  included in this analysis. A total of 10,264 patients reported history  of PD. Results: During a mean follow-up of 5 years, 2,921 patients  died, from which 1,461 had a CV death. The crude, age adjusted RR,  showed an association between PD and total mortality (RR=1.31, C.I.  1.2-1.4, p&lt;0.0001). Men with PD were more likely to have history of  diabetes, hypertension, stable angina, diabetes, and past or current  smoking, all with p&lt;0.001. The association between PD and total  mortality was substantially attenuated after adjustment for potential  confounders (RR=1.14, C.I. 1.02-1.26, p=0.02). Smoking appeared to be  an effect modifier because the crude RR between PD and mortality in  current or past smokers (RR=1.33, C.I. 1.2-1.5, p&lt;0.0001) was not  significantly attenuated after adjustment for potential confounders  (RR=1.25, C.I. 1.1-1.4, p&lt;0.0005). A similar association was found  with CV mortality, seetable. Conclusion: This prospective cohort study  suggests that PD is associated with increased mortality, particularly  among smokers. However, whether this mild association is real or only  due to residual confounding remains to be  clarified.Table 1.

Periodontal Disease Was Mildly Associated With an Increased Mortality in 88,882 Men.