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P28 Background: Several studies have indicated that prenatal  condition may affect cardiovascular risk factors and thereby risk of  cardiovascular morbidity and mortality. Based on these findings it has  been suggested that impaired intra-uterine growth leads to increased  risk of atherosclerosis. Data directly relating prenatal factors to  vascular changes are limited and restricted to older individuals. In  the ARYA study we evaluated whether birth characteristics are  associated with subclinical atherosclerosis in young adults. Methods:  The ARYA-study is a cohort study of 750 men and women aged 27-30 years.  Information on birth characteristics (gestational age, birth weight,  birth length) was obtained from the municipal health service medical  files. At baseline, information on cardiovascular risk factors was  obtained by questionnaire and measurements during two visits at the  research centre. Arterial characteristics were non-invasively assessed  by measuring common carotid intima-media thickness (CIMT) at both  carotid arteries and by measuring aortic stiffness by pulse wave  velocity (PWV). At present, data on 204 subjects are available for  analysis. Linear regression analysis was applied and results are  adjusted for age, gender, smoking and family history. Results: This  sub-analysis comprised of 204 young adults (47% men) with a mean age  of 29.2 (0.5). Mean gestational age was 39.8 (1.8) weeks, birth weight  3420 (539) gram, birth length 51.0 (2.5) cm, CIMT 0.51 (0.05) mm and  mean PWV 6.2 (1.0) m/s. With increasing gestational age (in weeks),  CIMT decreased with 0.006 mm [CI: -0.010, -0.002], whereas PWV  decreased with 0.112 m/s [CI: -0.217, -0.008]. These associations  were independent of birth weight. Conclusion: This preliminary analysis  of the ARYA-study indicates that decreased gestational age relates to  subclinical atherosclerosis already in young  adulthood.

Gestational age and arterial characteristics at 29 years of age in the Atherosclerosis Risk in Young Adults (ARYA) study.