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P26 Objective: To determine the magnitude and the shape of the  relation between left ventricular mass (LVM) and cardiovascular event  (CVD) rates in African-Americans (AA). Background: Left ventricular  hypertrophy on echocardiography is a powerful and independent CVD risk  factor. Previous studies indicate a monotonic relation of increasing  LVM index with increasing CVD rates in the general population (mostly  whites). However, the relation between LVM index and incident CVD in AA  has not been addressed. Methods: The Atherosclerosis Risk in  Communities (ARIC) is an ongoing cohort study of CVD in 4 US  communities. During the third visit, LVM was measured by  echocardiography in AA from Jackson, MS (1,975 participants free of  prevalent CVD, age range: 49-75, mean 58.9±1.5). Measurements were  taken according to the ASE recommendations. LVM was calculated as  (0.8[1.04((IVS+LVID+PWT) 3 -LVID 3 )]+ 0.6  g) and normalized by height 2.7 . Results: At a mean follow  up of 2.95 years, range (0.03-4.4) there were 63 cardiovascular events  (non-fatal MI= 19, fatal CHD= 8, non-fatal/fatal stroke= 30/8 and  cardiac procedure= 4; 8 participants had more than one type of event)  corresponding to an event rate of 1.08/100 patient-years. In the four  quartiles of LVM index distribution (partition values: 38, 47, 57, and  162 g/m 2.7 ), CVD rates were 0.33, 0.80, 0.83, and 2.51 per  100 patient-years respectively (p-value for trend= 0.002). After  adjustment for traditional risk factors (age, gender, smoking,  diabetes, hypertension, obesity and education level), the relative risk  of developing CVD increased progressively along a continuum of LVM  index values (RR 1.24/per each 10 g/m 2.7 , 95%CI  1.10-1.39). Conclusion: Our findings showed a linear, powerful, and  independent relation between LVM index and cardiovascular risk in AA  who were free from overt cardiovascular disease at the time of the  exam. Echocardiographic estimation of LVM index may be a useful tool  for assessment of total CVD risk in AA.

Continuous Relation in Risk Between Left Ventricular Mass and Cardiovascular Disease Incidence in African-Americans