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P01 OBJECTIVE. To assess whether dietary intake of fatty fish is  associated with a reduced risk of ischemic heart disease mortality in  older adults. BACKGROUND. Dietary intake of fatty fish has been  associated with a reduced risk of fatal ischemic heart disease in  middle-aged men and women. This association, however, has not been  specifically evaluated in older adults. METHODS. In 3968 men and  women ≥ age 65 enrolled in the Cardiovascular Health Study and  free of known cardiovascular disease at baseline, dietary intake of  fish (fried fish, tuna fish, and other fish) was assessed through a  detailed picture-sort food frequency questionnaire. In a subset of 348  persons, dietary intake of tuna and other fish combined (“fatty  fish”) correlated with plasma phospholipid levels of combined  docosahexaenoic acid (DHA, 22:6 n-3)) and eicosapentaenoic acid (EPA,  20:5 n-3) (r = 0.40, p &lt; 0.001); intake of fried fish did  not correlate with plasma phospholipid levels of these long-chain n-3  fatty acids (r = 0.05, p = 0.37). Participants were  prospectively followed for a mean period of 6.8 years for death from  ischemic heart disease (incident fatal myocardial infarction [MI]  plus coronary heart disease death) and nonfatal MI. FINDINGS. Compared  to intake of less than one serving of fatty fish per week, intake of at  least one serving of fatty fish per week was associated with a 35%  lower risk of death from ischemic heart disease (hazard ratio [HR]  0.65; 95% confidence interval [CI] 0.45 to 0.94) but was not  associated with a lower risk of nonfatal MI (HR 0.86; 95% CI 0.64 to  1.15), after adjustment for age, gender, diabetes, smoking status,  education, and total caloric intake. CONCLUSIONS. These findings  suggest that consumption of at least one serving of fatty fish per week  is associated with a lower risk of death from ischemic heart disease in  persons aged 65 years and older.

circulation

Finalists, The Jeremiah and Rose Stamler Research Award for New Investigators Fatty fish consumption and ischemic heart disease mortality in older adults: The Cardiovascular Health Study