English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Acute aortic dissection or rupture in Marfan syndrome or other aortopathies is an important cause of sudden death in athletes.1 Increased blood pressure and aortic stress during intense physical exertion place the patient with Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysm (TAA) and dissection syndrome, bicuspid aortic valve (BAV) aortopathy, aortic aneurysm, or other genetically triggered aortic diseases at risk for aortic catastrophe from aortic dissection or rupture or may accelerate aneurysm formation. Therefore, for people with aortic disease or a condition associated with aortic disease, discussion about safe levels of low-intensity, noncompetitive exercise should be emphasized beginning at a young age. This is important for a healthy lifestyle and to prevent social stigmatization, which may occur when physical activity is restricted excessively in young people.Marfan syndrome, an autosomal dominant disorder of connective tissue with an estimated prevalence of 1 in 5000 to 10 000, is caused by abnormal fibrillin-1 attributable to mutations in the FBN1 gene.2 Manifestations involve multiple organ systems, including the aorta, heart and valves, skeleton, eye, lungs, and dura. FBN1 mutations can be identified in the vast majority of patients satisfying the revised Ghent criteria for Marfan syndrome.2 The diagnosis of Marfan syndrome is made by use of clinical criteria, imaging, family history, and genetic testing as outlined in the revised Ghent criteria (Tables 1 and 2).2 Cardiovascular features of Marfan syndrome include mitral valve prolapse, mitral regurgitation, aortic root dilatation (most pronounced at the sinuses of Valsalva), and aortic dissection.2 The descending aorta, although less commonly involved in young patients, is also at risk for aneurysm formation and dissection.View this table:Table 1. Revised Ghent Criteria for the Diagnosis of Marfan SyndromeOther genetically triggered aortic aneurysm syndromes and conditions associated with aortopathy may increase the risk of aortic dissection in competitive athletes. …

circulation

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 7: Aortic Diseases, Including Marfan Syndrome