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Endothelial lipase (EL) is a key determinant in plasma high-density lipoprotein-cholesterol. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis.

Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet–Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits