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Objective— Abdominal aortic aneurysms (AAAs), dilations of the infrarenal aorta, are characterized by inflammation and oxidative stress. We previously showed increased levels of peroxiredoxin-1 (PRDX-1) in macrophages cultured from AAA patients. The purpose of the study was to determine which subpopulation of macrophages is present in AAAs and is involved in upregulation of PRDX-1 in aneurysmal disease. Methods and Results— This study used immunohistochemistry with antibodies against CD68 and mannose receptor (MR) to determine the subtype of macrophages in AAA tissue samples (n=33); laser capture microdissection to isolate each subtype; and quantitative–reverse transcriptase-polymerase chain reaction, Western blot, and ELISA to assessPRDX-1 mRNA and PRDX-1protein levels in both types. Proinflammatory CD68+ MR− macrophages predominated in adventitial tissue, whereas the intraluminal thrombus contained CD68+ MR+ macrophages. The presence of lipids and iron-containing deposits confirmed their phagocytic phenotype. Laser capture microdissection-isolated CD68+ MR− and CD68+ MR+ macrophages, characterized by quantitative–reverse transcriptase-polymerase chain reaction (TNF ,IL1B ,MRC1 , andCCL18 ) and Western blot (stabilin and hemoglobin), validated the microdissected subtypes. PRDX-1 expression was colocalized with CD68+ MR− macrophages.PRDX-1 mRNA and PRDX-1 protein were both more abundant in CD68+ MR− than CD68+ MR+ macrophages in AAA.Conclusion— These findings suggest that the proteins or mRNAs expressed by the proinflammatory CD68+ MR− macrophages may contribute to aneurysmal pathology.

arteriosclerosis, thrombosis, and vascular biology

Role of Proinflammatory CD68 <sup>+</sup> Mannose Receptor <sup>−</sup> Macrophages in Peroxiredoxin-1 Expression and in Abdominal Aortic Aneurysms in Humans

Role of Proinflammatory CD68 + Mannose Receptor − Macrophages in Peroxiredoxin-1 Expression and in Abdominal Aortic Aneurysms in Humans

Role of Proinflammatory CD68 ⁺ Mannose Receptor ⁻ Macrophages in Peroxiredoxin-1 Expression and in Abdominal Aortic Aneurysms in Humans