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Nascent high-density lipoprotein (HDL) particles form from cellular lipids and extracellular lipid-free apolipoprotein AI (apoAI) in a process mediated by ATP-binding cassette transporter A1 (ABCA1). We have sought out compounds that inhibit nascent HDL biogenesis without affecting ABCA1 activity.

arteriosclerosis, thrombosis, and vascular biology

A Novel Compound Inhibits Reconstituted High-Density Lipoprotein Assembly and Blocks Nascent High-Density Lipoprotein Biogenesis Downstream of Apolipoprotein AI Binding to ATP-Binding Cassette Transporter A1–Expressing Cells