Open AccessGlucagon-Like Peptide 1 Prevents Reactive Oxygen Species–Induced Endothelial Cell Senescence Through the Activation of Protein Kinase A
Author(s) -
Hisko Oeseburg,
Rudolf A. de Boer,
Hendrik Buikema,
Pim van der Harst,
Wiek H. van Gilst,
Herman H.W. Silljé
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.110.206425
Subject(s) - senescence , oxidative stress , endocrinology , umbilical vein , medicine , biology , reactive oxygen species , creb , dipeptidyl peptidase 4 , microbiology and biotechnology , biochemistry , transcription factor , diabetes mellitus , in vitro , type 2 diabetes , gene
Endothelial cell senescence is an important contributor to vascular aging and is increased under diabetic conditions. Here we investigated whether the antidiabetic hormone glucagon-like peptide 1 (GLP-1) could prevent oxidative stress-induced cellular senescence in endothelial cells.
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