English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Objective— To generateAbcg1 −/− Apoe −/− mice to understand the mechanism and cell types involved in changes in atherosclerosis after loss of ABCG1.Methods and Results— ABCG1 is highly expressed in macrophages and endothelial cells, 2 cell types that play important roles in the development of atherosclerosis.Abcg1 −/− Apoe −/− andApoe −/− mice and recipientApoe −/− mice that had undergone transplantation with bone marrow fromApoe −/− orAbcg1 −/− Apoe −/− mice were fed a Western diet for 12 or 16 weeks before quantification of atherosclerotic lesions. These studies demonstrated that loss of ABCG1 from all tissues, or from only hematopoietic cells, was associated with significantly smaller lesions that contained increased numbers of TUNEL- and cleaved caspase 3–positive apoptoticAbcg1 −/− macrophages. We also identified specific oxysterols that accumulate in the brains and macrophages of theAbcg1 −/− Apoe −/− mice. These oxysterols promoted apoptosis and altered the expression of proapoptotic genes when added to macrophages in vitro.Conclusion— Loss of ABCG1 from all tissues or from only hematopoietic cells results in smaller atherosclerotic lesions populated with increased apoptotic macrophages, by processes independent of ApoE. Specific oxysterols identified in tissues ofAbcg1 −/− Apoe −/− mice may be critical because they induce macrophage apoptosis and the expression of proapoptotic genes.

Impaired Development of Atherosclerosis in Abcg1 −/− Apoe −/− Mice

Impaired Development of Atherosclerosis in Abcg1 ^−/− Apoe ^−/− Mice