Open AccessImproved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7)
Author(s) -
Sérgio Henrique Sousa Santos,
Janaina F Braga,
Érica Guilhen Mário,
Laura Cristina Jardim Pôrto,
Maria da Glória RodriguesMachado,
A Murari,
Leida Maria Botion,
Natália Alenina,
Michael Bäder,
Robson A.S. Santos
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.200493
Subject(s) - endocrinology , medicine , metabolism , genetically modified mouse , transgene , carbohydrate metabolism , angiotensin ii , lipid metabolism , chemistry , renin–angiotensin system , biology , biochemistry , blood pressure , gene
Obesity and diabetes remain among the world's most pervasive health problems. Although the importance of angiotensin II for metabolic regulation is well documented, the role of the angiotensin-(1-7)/Mas axis in this process is poorly understood. The aim of this study was to evaluate the effect of increased angiotensin-(1-7) plasma levels in lipid and glucose metabolism using transgenic rats that express an angiotensin-(1-7)-releasing fusion protein, TGR(A1-7)3292 (TGR).
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