Open AccessPharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E −/− Mouse: Magnetic Resonance Imaging Assessment
Author(s) -
Alan R. Olzinski,
Gregory Turner,
Roberta E. Bernard,
Heather Karr,
Carla Cornejo,
Karpagam Aravindhan,
Bao Hoang,
Michael A. Ringenberg,
Pu Qin,
Krista Goodman,
Robert N. Willette,
Colin H. Macphee,
Beat M. Jucker,
Clark A. Sehon,
Peter J. Gough
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.198812
Subject(s) - chemokine , infiltration (hvac) , chemokine receptor , apolipoprotein e , receptor , magnetic resonance imaging , chemistry , ccl21 , macrophage , ccr2 , inflammation , pathology , biology , immunology , medicine , biochemistry , materials science , in vitro , composite material , radiology , disease
Purpose- This study assessed the pharmacological effect of a novel selective C-C chemokine receptor (CCR) 2 antagonist (GSK1344386B) on monocyte/macrophage infiltration into atherosclerotic plaque using magnetic resonance imaging (MRI) in an atherosclerotic mouse model.
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