Open AccessA Common Variant in Low-Density Lipoprotein Receptor–Related Protein 6 Gene (LRP6) Is Associated With LDL-Cholesterol
Author(s) -
Maciej Tomaszewski,
Fadi J. Charchar,
Timothy Barnes,
Magdalena Gawron-Kiszka,
Agnieszka Sędkowska,
Ewa Podolecka,
Jacek Kowalczyk,
Wendy E. Rathbone,
Zbigniew Kalarus,
W Grzeszczak,
Alison H. Goodall,
Nilesh J. Samani,
E Żukowska-Szczechowska
Publication year - 2009
Publication title -
arteriosclerosis, thrombosis, and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.185355
Subject(s) - minor allele frequency , medicine , endocrinology , allele , cholesterol , genetics , allele frequency , single nucleotide polymorphism , family history , biology , genotype , gene
A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was identified as the primary molecular defect underlying monogenic form of coronary artery disease. We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C).