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Macrophages produce the cytokine oncostatin M (OSM), which beside other functions is also involved in inflammation. The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined the effect of C5a on OSM production in human monocytes and in human monocyte-derived macrophages.

In Human Macrophages the Complement Component C5a Induces the Expression of Oncostatin M via AP-1 Activation