Open AccessSegregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation
Author(s) -
Imke C.A. Munnix,
Marijke J. E. Kuijpers,
Jocelyn M. Auger,
Stella Thomassen,
Peter Panizzi,
Marc A.M. van Zandvoort,
Jan Rosing,
Paul Bock,
Steve P. Watson,
Johan W. M. Heemskerk
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.151100
Subject(s) - platelet , thrombus , coagulation , thrombin , phosphatidylserine , fibrin , chemistry , platelet activation , platelet adhesiveness , biophysics , population , fibrinogen , integrin , microbiology and biotechnology , biochemistry , immunology , biology , receptor , medicine , platelet aggregation , membrane , phospholipid , environmental health
Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation. We investigated the commitment of platelets to these separate functions during collagen-induced thrombus formation in vitro and in vivo.
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