Open AccessRole of Endothelial Nitric Oxide Generation and Peroxynitrite Formation in Reperfusion Injury After Focal Cerebral Ischemia
Author(s) -
Yasemin Özdemir,
Hayrünnisa Bolay,
Okay Sarıbaş,
Turgay Dalkara
Publication year - 2000
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.31.8.1974
Subject(s) - peroxynitrite , evans blue , nitrotyrosine , reperfusion injury , medicine , nitric oxide , extravasation , nitric oxide synthase , ischemia , pharmacology , anesthesia , superoxide , pathology , biochemistry , chemistry , enzyme
Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis. Surges of nitric oxide (NO) and superoxide generation on reperfusion have been demonstrated. Concomitant generation of these radicals can lead to formation of the strong oxidant peroxynitrite during reperfusion.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom