Open AccessInhibition by ketanserin of serotonin induced cerebral arteriolar constriction.
Author(s) -
JA Thompson,
E. P. Wei,
H. A. Kontos
Publication year - 1984
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.15.6.1021
Subject(s) - ketanserin , serotonin , constriction , medicine , microcirculation , stimulation , anesthesia , cerebral circulation , 5 ht receptor , endocrinology , pharmacology , receptor
We studied the effects of serotonin on pial arterioles in anesthetized cats equipped with acutely implanted cranial window for the observation of the pial microcirculation. Serotonin topically applied caused cerebral arteriolar constriction. Ketanserin, a specific 5-HT2 inhibitor, completely blocked the vascular response of serotonin. Aggregated platelet supernatant was topically applied and caused generalized cerebral arteriolar constriction that could be blocked with ketanserin. We conclude that serotonin causes generalized cerebral arteriolar constriction that is due to the stimulation of 5-HT2 receptor. Aggregating platelets release serotonin, which mediates the vasoconstrictive action of the supernatant solution.
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