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To the Editor:In their recent publication regarding interpretation of the Stroke-Acute Ischemic NXY Treatment (SAINT I) trial,1 Koziol and Feng use the definition, but not the derivation method, for number-needed-to-treat (NNT) and number-needed-to-harm (NNH) that was previously described.2 As a result they arrive at biologically untenable estimates of NNT and NNH.A challenge in deriving NNT and NNH values for ordinal scale responses is that parallel group trial results do not specify the within-patient correlation—the degree to which the rank order …

Deriving Number-Needed-to-Treat and Number-Needed-to-Harm From the Saint I Trial Results