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It has been proposed that purely unilateral carotid stenosis is due mainly to local hemodynamic factors, whereas more diffuse disease reflects a systemic as well as a local predisposition and should therefore be associated with higher rates of arterial disease in the other territories. However, few studies have tested this hypothesis.

Risk of Coronary and Other Nonstroke Vascular Death in Relation to the Presence and Extent of Atherosclerotic Disease at the Carotid Bifurcation