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Although white matter is a potential target of acute stroke therapy, there is uncertainty about its relative resistance to ischemia and whether it is capable of mounting a penumbral response. To explore these issues further, we examined the differential effects of ischemia on gray and white matter using magnetic resonance (MR) perfusion-diffusion mismatch after acute stroke.

The Existence and Evolution of Diffusion–Perfusion Mismatched Tissue in White and Gray Matter After Acute Stroke