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Background and Purpose— The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the α1 -antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation. The A/T polymorphism of theSERPINA3 gene influences expression of SERPINA3 protein. SERPINA3 can be related to aneurysmal subarachnoid hemorrhage (SAH) by influencing inflammation or by regulating cathepsin G activity. We studied the significance ofSERPINA3 A/T polymorphism in patients with aneurysmal SAH compared with healthy controls.Methods— A total of 180 patients with aneurysmal SAH and 263 healthy controls were genotyped for theSERPINA3 A/T polymorphism. Aneurysmal SAH was diagnosed by cranial computed tomography or lumbar puncture and digital subtraction angiography.SERPINA3 polymorphism was detected by polymerase chain reaction amplification and restriction enzyme digestion.Results— TheSERPINA3 genotype distribution in patients with aneurysmal SAH (AA-29 16.1%; AT-108 60.0%; TT-43 23.9%) differed significantly from controls (AA-70 26.6%; AT-123 46.8%; TT-70 26.6%;P =0.009). A logistic regression model showed that the presence of genotype with T allele (AT+TT; odds ratio [OR], 2.01; 95% CI, 1.19 to 3.38;P =0.009) or AA genotype (OR, 0.49; 95% CI, 0.30 to 0.84;P =0.009) of theSERPINA3 influences the risk for aneurysmal SAH independently from smoking, excessive alcohol consumption, and hypertension.Conclusion— The A/T polymorphism ofSERPINA3 gene is associated with the risk factor for aneurysmal SAH.

α1-Antichymotrypsin Gene (SERPINA3) A/T Polymorphism as a Risk Factor for Aneurysmal Subarachnoid Hemorrhage

α₁-Antichymotrypsin Gene (SERPINA3) A/T Polymorphism as a Risk Factor for Aneurysmal Subarachnoid Hemorrhage