Open AccessA Genome-Wide Scan for Carotid Artery Intima-Media Thickness
Author(s) -
Dai Wang,
Huiying Yang,
Manuel J. Quiñones,
Isabel BulnesEnriquez,
Xochitl Jimenez,
Roxana De La Rosa,
Tamara Modilevsky,
K.-H. Yu,
Yanjie Li,
Kent D. Taylor,
Willa A. Hsueh,
Howard N. Hodis,
Jerome I. Rotter
Publication year - 2005
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.0000155746.65185.4e
Subject(s) - medicine , intima media thickness , heritability , cardiology , coronary artery disease , genetic linkage , linkage (software) , chromosome , genetics , gene , carotid arteries , biology
Carotid artery intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with coronary artery disease (CAD), and stroke. CIMT is also an important predictor of clinical cardiovascular events. To systematically identify the genetic determinants of CIMT, we performed a genome-wide scan using data from 91 2-generation Mexican American families ascertained via a parent with CAD diagnosed.
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