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To the Editor:We read with interest the recent article by Kelly and colleagues1 dealing with the relationship among serum vitamin B6 measured as pyridoxal 5′-phosphate (PLP), serum total homocysteine (tHcy), and C-reactive protein (CRP) in patients after ischemic stroke. The results of their study with univariate and multivariable analyses demonstrated that among stroke patients, CRP was a predictor of PLP. In addition, they indicated that among control subjects, both CRP and tHcy were independent predictors of PLP, although there was no association between CRP and tHcy. The authors proposed that vitamin B6 but not tHcy might be a marker of inflammatory status and vascular diseases.There is evidence that homocysteines might disturb the bioavailability of nitric oxide (NO), which would, …

Homocysteine, Vitamin B6, and Endothelial Dysfunction in Circulatory Disorders