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To the Editor:The research report by the EVA-3S Investigators1 has implications which could far exceed their understandable desire to optimize safety within the trial. Following an early interim analysis, the investigators observed that the death/stroke rate after unprotected carotid angioplasty was 10.3% (6/58), as compared with 26.7% (4/15) following unprotected angioplasty. This led to a recommendation that all future angioplasties in the trial should be performed with protection. This is despite the fact that the trial was neither powered to make this judgment, nor was the difference statistically significant.I can readily sympathize with the dilemma faced by the Investigators but, in publishing this alert, they have probably rendered continuation of …

Premature Trial Suspension Will Inevitably Alter Equipoise