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To the Editor:Roffe and colleagues provide an excellent study on a large patient population proving the high prevalence of hypoxia in acute, mostly ischemic stroke patients.1 They showed that “… many stroke patients who appear normoxic during the day may develop significant hypoxia at night early after the stroke” because stroke patients spent more time in hypoxia and had significantly higher oxygen desaturation index (ODI). The authors call attention to the increased danger of hypoxia for developing definitive brain infarctions during brain ischemia, when compensating vasodilatation-capacity of the brain vessels is lost. On the basis of their results, oxygen monitoring of acute stroke patients, especially during sleep, seems to be clearly justified.The authors state: “because we do not have data on oxygen saturation before the stroke, it is not possible to say whether the difference in oxygen saturation between stroke patients and control subjects is …

Is Sleep-Hypoxia Really Unexpected in Acute Stroke?