Open AccessMatrix Metalloproteinase-9 and Myeloperoxidase Expression
Author(s) -
Carolina M. Maier,
Lily B. Hsieh,
Fengshan Yu,
Paige M. Bracci,
Pak H. Chan
Publication year - 2004
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.0000125861.55804.f2
Subject(s) - extravasation , evans blue , myeloperoxidase , medicine , sod2 , ischemia , matrix metalloproteinase , superoxide dismutase , pathology , extracellular matrix , andrology , immunology , inflammation , endocrinology , biology , oxidative stress , biochemistry
Expression of matrix metalloproteinases (MMPs), proteolytic enzymes that degrade extracellular proteins, is altered after ischemia/reperfusion injury and may contribute to blood-brain barrier (BBB) breakdown. Neutrophils, a source of reactive oxygen species and MMP-9, infiltrate damaged tissue 6 to 24 hours after ischemia and have also been implicated in delayed secondary tissue damage. Here we examined the spatial-temporal relation between MMP-9 expression and neutrophil infiltration after stroke.
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