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Patients with patent foramen ovale (PFO) experiencing ischemic cerebrovascular symptoms should not routinely undergo closure. A clear relationship between PFO and stroke has not yet been proven. Even if PFOs are shown to predispose to stroke, medical therapies for stroke prevention in patients with PFOs have not been adequately tested, making comparisons with invasive treatment difficult, and probably premature.Several small, uncontrolled studies have suggested a relationship between PFO and stroke. Recent data, however, indicate that these studies may overestimate the association. In one study, PFOs were found in 20.8% of 519 randomly selected asymptomatic community-based controls compared with 16.5% of 158 patients referred for evaluation of cryptogenic stroke, demonstrating no increase in the prevalence of PFO among patients with stroke compared with a random nonhospitalized reference population.1Only 2 prospective multicenter studies of substantial size have evaluated the stroke recurrence risk in patients with PFO. These studies provide the best data for guiding the management of patients with PFO and ischemic cerebrovascular events.The French PFO-ASA Study Group evaluated 216 young patients (aged 18 to 55, mean age 40) with PFO and cryptogenic stroke and compared them with …

Patent Foramen Ovale and Recurrent Stroke: Closure is the Best Option: Yes