Open Access4G/4G Genotype of PAI-1 Gene Is Associated With Reduced Risk of Stroke in Elderly
Author(s) -
Tiny Hoekstra,
Johanna M. Geleijnse,
Cornelis Kluft,
Erik J. Giltay,
Frans J. Kok,
Evert G. Schouten
Publication year - 2003
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.0000098004.26252.eb
Subject(s) - medicine , stroke (engine) , genotype , relative risk , myocardial infarction , fibrinolysis , allele , plasminogen activator inhibitor 1 , population , plasminogen activator , gastroenterology , confidence interval , gene , genetics , engineering , mechanical engineering , biology , environmental health
Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele. We investigated whether plasma PAI-1 and 4G/5G genotype would predict the occurrence of cardiovascular events at old age.
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