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Background and Purpose— It has been suggested that the interleukin-1A (IL-1A ) allele 2 is a risk factor for Alzheimer’s disease (AD). Because cerebral amyloid angiopathy–related hemorrhage (CAAH) often coexists with AD, we examined theIL-1A polymorphism in CAAH.Methods— In a case-control study, patients with pathologically verified CAAH, AD patients without intracerebral hemorrhage, and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, andIL-1A was genotyped. Logistic regression was used to examine theIL-1A polymorphism in CAAH patients with and without AD compared with AD and non-AD control subjects.Results— There were 42 patients with CAAH, 232 AD patients, and 167 non-AD control subjects. In age-adjusted analyses, there was no association between possession ofIL-1A allele 2 and risk of CAAH compared with AD control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97;P =0.87) or non-AD control subjects (OR, 0.94; 95% CI, 0.47 to 1.87;P =0.86). Stratifying for the presence of apolipoprotein E ε2 or ε4 demonstrated the known increased risk of CAAH from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of theIL-1A 2,2 genotype in patients with CAAH and AD compared with those CAAH patients who did not have histological evidence indicating AD (OR, 2.17; 95% CI, 0.15 to 122.3;P =0.64). Comparisons between CAAH patients with AD and AD control subjects and between CAAH patients without AD and non-AD control subjects did not demonstrate an association between CAAH and possession of either theIL-1A allele 2 or the 2,2 genotype.Conclusions— TheIL-1A allele 2 or 2,2 genotype does not appear to be a major risk factor for CAAH.

Association Between Interleukin-1A Polymorphism and Cerebral Amyloid Angiopathy–Related Hemorrhage