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AS OF SPECIAL INTEKEST to this group I have chosen to review briefly some of our studie's of the relation of the rate of aldosterone secretion to the pathogenesis of arterial hypertension in man. Analysis of this relationship has been complicated by several considerations. First, the various known forms of high blood pressure cannot be traced to the saine cause. Second, no clear-cut patterns of biochemical abnormality seem to characterize any large proportion of these patients. As a result, partly of these limitations, the study and classification of human types of hypertension have been largely descriptive. Investigators have long associated a disorder of salt metabolism with hypertension. Moreover, they have thought that a sodiumretaining hormone of the adrenal cortex was in some way involved in this relationship. Today an enormous body of evidence suggests strongly that there is a connection between the adrenal cortex and both experimental hypertension and high blood pressure occurring as a disease state in man. Although a review of this material is impossible here, it should be pointed out that apparently mineralocorticoids such as aldosterone do not affect blood pressure directly, but influence it indirectly through their effects on sodium and potassium balance. Aldosterone was first studied in relation to hypertension by Genest and his associates.' " These workers found that the mean urinary excretion of aldosterone was increased significantly in 55 per cent of patients with essen-

Relation of Aldosterone Secretion to Hypertensive Vascular Disease