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Augmented reactivity of the skin vessels of the hind limbs of dogs to doses of l-epinephrine in the physiologic range could not be detected following conventional sympathectomy. Larger doses of epinephrine resulted in exaggerated reactions. Augmented reactivity of these vessels to physiologic doses of epinephrine was detectable if total cholinergic as well as adrenergic denervation of the limb was accomplished.

Responses of Dog's Pad Vessels to Epinephrine Following Sympathectomy or Denervation