Open AccessEffect of pH Change upon Renal Vascular Resistance and Urine Flow
Author(s) -
D. A. Emanuel,
MALCOLM FLEISHMAN,
F. J. Haddy,
Jerry Scott
Publication year - 1957
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.5.6.607
Subject(s) - vascular resistance , kidney , endocrinology , chemistry , medicine , vascular smooth muscle , renal blood flow , flow resistance , hemodynamics , smooth muscle , flow (mathematics) , mathematics , geometry
In the dog kidney, acute increase and decrease in hydrogen ion concentration results in decrease and increase in renal vascular resistance respectively. These changes occur predominantly on the alkaline side of pH 7.3 and result from some direct effect upon vascular smooth muscle. The re sistance changes are less apparent in nerve intact than nerve sectioned kidneys due to opposing effects mediated through extrinsic nerves.
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