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The purpose of this study was to determine the relative influence of arterial baroreceptors and of cardiac receptors with vagal afferents on efferent cardiac sympathetic nerve activity during coronary artery occlusion. Changes in heart rate (beats/min), arterial pressure (mm Hg), and integrated cardiac sympathetic nerve activity (CSNA, percent change from control; recorded from the cut central end of the left ventral ansa subclavia) were determined during transient (90-second) circumflex (Cx) and anterior descending (LAD) coronary artery occlusions. In dogs with carotid and aortic baroreceptors intact, increases (mean ± SE) in CSNA during Cx (7 ± 2%) and LAD (9 ± 5%) occlusions were similar despite a significantly greater fall in arterial pressure during Cx (-14 ± 3 mm Hg) than during LAD (−5 ± 2 mm Hg) coronary artery occlusion. Heart rate did not change during these occlusions. In three dogs, hypotension induced by inferior vena caval occlusion resulted in greater increases in CSNA than did comparable decreases in arterial pressure resulting from occlusion of LAD or Cx. In dogs with sinoaortic denervation, Cx coronary occlusion resulted in decreases in CSNA (-14 ± 4%), arterial pressure (−38 ± 6 mm Hg), and heart rate (-13 ± 5 beats/min), whereas LAD occlusion resulted in a small decrease in arterial pressure (-12 ± 5 mm Hg) and no change in CSNA or heart rate. Vagotomy abolished the decreases in CSNA and heart rate and attenuated the arterial pressure responses to Cx occlusion. We conclude that cardiac receptors with vagal afferents exert an inhibitory influence on cardiac sympathetic nerve activity during myocardial ischemia, particularly during inferoposterior ischemia, and that this influence limits the arterial baroreceptor-mediated increases in CSNA resulting from ischemia-induced hypotension. Circ Res 45: 728-736, 1979

circulation research

Interaction between cardiac receptors and sinoaortic baroreceptors in the control of efferent cardiac sympathetic nerve activity during myocardial ischemia in dogs.