English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We determined the effects of direct renal intra-arterial injections of [des-Asp angiotensin I (0.2-3.2 pg) and angiotensin HI (0.00625-0.1 fig) on renal blood flow in 10 dogs anesthetized with pentobarbitaL Both [des-Asp*]angiotensin I and angiotensin HI caused dose-dependent decreases in renal blood flow. The decreases in ipsilateral renal blood flow occurred in the absence of alterations in systemic arterial pressure and flow to the contralateral kidney, suggesting that the response was a local event. The renovascular responses to [des-Asp'jangiotensin I were greatly attenuated during the intravenous administration of SQ 20881, a synthetic peptide that competitively inhibits angiotensin converting enzyme., SQ 20881 did not alter the vasoconstrictor responses to angiotensin EH, angiotensin n, or norepinephrine. [Ue'jAngiotenain HI (an angiotensin HI antagonist) abolished decreases in renal blood flow produced by [des-Asp'langiotenflin L, angiotensin H angiotensin HL and angiotensin I, whereas the response to norepinephrine was unchanged. These results suggest that the decrease in renal blood flow produced by [des-Asp'Jangiotensin I is due to its local enzymatic conversion to angiotensin HI. About 7% of [des-Asp'Jangiotensin I is converted to angiotensin HI during one transit through the kidney. Circ Res 44:666-671, 1979

Intrarenal vascular effects of [des-Asp1] angiotensin I and angiotensin III in the dog.