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The observation of susceptibility to atrial fibrillation in the thyrotoxic patient suggests a method by which a similar condition may be produced in dogs. This has been accomplished by long-term thyroid extract feeding. Administration of acetylcholine to these dogs by intravenous injection has resulted in a high percentage (81 per cent) of atrial fibrillation.

Production of Atrial Fibrillation in Dogs by Thyroid Administration and Acetylcholine Injection